VSNR51 Neuroradiology Series: Brain Tumors
نویسندگان
چکیده
Depths of novel imaging biomarkers are now available for evaluating biological response to new therapies in CNS tumors. The current course will briefly outline the current Response Assessment in Neuro-Oncology (RANO) criteria, including limitations when implementing in multicenter trials. The use of digital T1 subtraction maps as a method for measuring enhancing tumor volume in the presence of agents that reduce vascular permeability will be discussed. T2/FLAIR response, challenges associated with interpreting T2/FLAIR response, and a potential solution for measuring nonenhancing tumor response using T2 relaxometry will be described. This course will outline simple and advanced diffusion MR biomarkers for patient stratification and response assessment, including ADC histogram analysis, functional diffusion mapping, voxel-wise proliferation and invasion modeling, and DREAM-MRI. Simple and advanced perfusion MR biomarkers, including DSC-MRI, DCE-MRI, and a new pharmacokinetic perfusion-diffusion model will be described. The use of pH-weighted MR response to therapy will also be discussed using CEST imaging. Lastly, basic and advanced PET imaging techniques will be described in the context of response assessment and drug target efficacy. The DTI Challenge Initiative on the Standardized Evaluation of DTI Tractography for Neurosurgical Planning Sonia Marie-Aurore Pujol PhD (Presenter): Nothing to Disclose , Ron Kikinis MD : Nothing to Disclose , Alexandra J. Golby MD : Nothing to Disclose , Carlo Pierpaoli : Nothing to Disclose , VSNR51-06
منابع مشابه
MR imaging: possibility of tissue characterization of brain tumors using T1 and T2 values.
To evaluate the usefulness of T1 and T2 values for tissue characterization of brain tumors, 37 histologically confirmed brain tumors were examined with a 0.5-T superconductive MR system. With spin-echo and inversion-recovery imaging sequences, computed T1 and T2 images were reconstructed, and T1 and T2 values of the tumors were calculated. Relaxation rates (1/T1 and 1/T2), T1/T2 ratios, and mal...
متن کاملUtility of diffusion tensor imaging in evaluation of the peritumoral region in patients with primary and metastatic brain tumors.
In the brain, diffusion tensor imaging is a useful tool for defining white matter anatomy, planning a surgical approach to space-occupying lesions, and characterizing tumors, including distinguishing primary tumors from metastases. Recent studies have attempted, with varying success, to use DTI to define the extent of tumor microinfiltration beyond the apparent borders on T2-weighted imaging. I...
متن کاملImaging findings of CNS atypical teratoid/rhabdoid tumors.
Four patients with brain tumors were diagnosed with atypical teratoid/rhabdoid tumors and underwent CT and MR imaging. For all tumors, aggressive features were shown by imaging studies and included hydrocephalus, apparent invasion of the adjacent brain and dura, and marked mass effect. The striking heterogeneity of the atypical teratoid/rhabdoid tumor shown by imaging studies reflects the histo...
متن کاملMRI characteristics of ependymoblastoma: results from 22 centrally reviewed cases.
BACKGROUND AND PURPOSE Ependymoblastoma is a malignant embryonal tumor that develops in early childhood and has a dismal prognosis. Categorized by the World Health Organization as a subgroup of CNS-primitive neuroectodermal tumor, ependymoblastoma is histologically defined by "ependymoblastic rosettes." Because it is so rare, little is known about specific MR imaging characteristics of ependymo...
متن کامل